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The age of genomics has infiltrated most biological disciplines, and Forestry is no exception. Genomic tools have led to fundamental insights about the ecology and evolutionary history of natural forests. Furthermore, genomics has actualized the promises of marker-aided selection by enabling whole genome prediction, which promises to revolutionize approaches to tree improvement. Genomic resources are reaching a critical mass for numerous species. We are now approaching an inflection point as forestry practitioners transition from the development of genomic resources as an end in itself, to application of genomics to problems of fundamental importance in forestry. This Special Issue explores this transition through a series of papers focusing on the application of genomics approaches to diverse aspects of forestry research.